EIF3L Rabbit pAb
Datasheet
Catalog Number:
E45R28811NAmount:
100 µlCite ID#:
EN5513123Price:
409$Type:
Polyclonal AntibodiesHost:
RabbitReactivity:
Human, Mouse, RatImmunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human EIF3L (NP_057175.1).Positive control:
HepG2, HT-1080, NIH/3T3, Mouse heart, Mouse pancreas, Mouse liverIsotype:
IgGPurification:
Affinity purificationGene ID:
51386Swiss-Prot No.:
Q9Y262Summary:
Component of the eukaryotic translation initiation factor 3 (eIF-3 complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC. The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.Form:
LiquidStorage/Stability:
Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.Dilution:
WB 1:1000 - 1:4000
IHC 1:50 - 1:200Altername:
EIF3L; EIF3EIP; EIF3S11; EIF3S6IP; HSPC021; HSPC025; MSTP005
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Catalog Number
- Amount:100 µl
- Price:409$
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