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METTL14 Rabbit pAb
Human, Mouse, Rat
WB (Human breast cancer, Homo sapiens, Mus musculus, Rattus norvegicus)
IF (Human breast cancer, Homo sapiens, Rattus norvegicus)
Co-IP (Homo sapiens)
IHC (Rattus norvegicus)
IF (Human breast cancer, Homo sapiens, Rattus norvegicus)
Co-IP (Homo sapiens)
IHC (Rattus norvegicus)
$409/ 100 µl
QuantityTotal: $409
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Cite ID#EN5515867
TypePolyclonal Antibodies
HostRabbit
Positive controlMouse testis, Rat testis, Rat brain
IsotypeIgG
SummaryThe METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6 position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis. In the heterodimer formed with METTL3, METTL14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core. N6-methyladenosine (m6A, which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing. M6A acts as a key regulator of mRNA stability by promoting mRNA destabilization and degradation (By similarity. In embryonic stem cells (ESCs, m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization (By similarity. M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis (By similarity. M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells (By similarity.
FormLiquid
Storage BufferBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Price409$
ImmunogenRecombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human METTL14 (NP_066012.1).
PurificationAffinity purification
Gene ID57721
Storage/StabilityStore at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
DilutionWB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200
IP 1:50 - 1:200
IHC 1:50 - 1:200
IF 1:50 - 1:200
IP 1:50 - 1:200
All Names
AlternameMETTL14; hMETTL14
Conjugated Antibody
This product is also available conjugated. Format: E45R28314N-Conjugate. Price: $485 / Size: 100μl.
E45R28314N-FITC$485 / 100μlE45R28314N-Biotin$485 / 100μlE45R28314N-HRP$485 / 100μlE45R28314N-AP$485 / 100μlE45R28314N-AF350$485 / 100μlE45R28314N-AF405M$485 / 100μlE45R28314N-AF488$485 / 100μlE45R28314N-AF514$485 / 100μlE45R28314N-AF532$485 / 100μlE45R28314N-AF555$485 / 100μlE45R28314N-AF568$485 / 100μlE45R28314N-AF405S$485 / 100μlE45R28314N-AF405L$485 / 100μlE45R28314N-AF546$485 / 100μlE45R28314N-AF594$485 / 100μlE45R28314N-AF610$485 / 100μlE45R28314N-AF635$485 / 100μlE45R28314N-AF647$485 / 100μlE45R28314N-AF680$485 / 100μlE45R28314N-AF700$485 / 100μlE45R28314N-AF750$485 / 100μlE45R28314N-AF790$485 / 100μlE45R28314N-APC$485 / 100μlE45R28314N-PE$485 / 100μlE45R28314N-Cy3$485 / 100μlE45R28314N-Cy5$485 / 100μlE45R28314N-Cy5.5$485 / 100μlE45R28314N-Cy7$485 / 100μlE45R28314N-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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