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DHX58 Rabbit pAb
$409/ 100 µl
QuantityTotal: $409
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Cite ID#EN5505715
TypePolyclonal Antibodies
HostRabbit
Positive controlMouse liver, Mouse brain, Rat liver
IsotypeIgG
SummaryActs as a regulator of DDX58/RIG-I and IFIH1/MDA5 mediated antiviral signaling. Cannot initiate antiviral signaling as it lacks the CARD domain required for activating MAVS/IPS1-dependent signaling events. Can have both negative and positive regulatory functions related to DDX58/RIG-I and IFIH1/MDA5 signaling and this role in regulating signaling may be complex and could probably depend on characteristics of the infecting virus or target cells, or both. Its inhibitory action on DDX58/RIG-I signaling may involve the following mechanisms: competition with DDX58/RIG-I for binding to the viral RNA, binding to DDX58/RIG-I and inhibiting its dimerization and interaction with MAVS/IPS1, competing with IKBKE in its binding to MAVS/IPS1 thereby inhibiting activation of interferon regulatory factor 3 (IRF3. Its positive regulatory role may involve unwinding or stripping nucleoproteins of viral RNA thereby facilitating their recognition by DDX58/RIG-I and IFIH1/MDA5. Involved in the innate immune response to various RNA viruses and some DNA viruses such as poxviruses and coronavirus SARS-CoV-2, and also to the bacterial pathogen Listeria monocytogenes. Can bind both ssRNA and dsRNA, with a higher affinity for dsRNA. Shows a preference to 5'-triphosphorylated RNA, although it can recognize RNA lacking a 5'-triphosphate.
FormLiquid
Storage BufferBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Price409$
ImmunogenRecombinant fusion protein containing a sequence corresponding to amino acids 389-678 of human DHX58 (NP_077024.2).
PurificationAffinity purification
Gene ID79132
Storage/StabilityStore at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
DilutionWB 1:500 - 1:2000
IF 1:50 - 1:200
IF 1:50 - 1:200
All Names
AlternameDHX58; D11LGP2; D11lgp2e; LGP2; RLR-3
Conjugated Antibody
This product is also available conjugated. Format: E45R28069N-Conjugate. Price: $485 / Size: 100μl.
E45R28069N-FITC$485 / 100μlE45R28069N-Biotin$485 / 100μlE45R28069N-HRP$485 / 100μlE45R28069N-AP$485 / 100μlE45R28069N-AF350$485 / 100μlE45R28069N-AF405M$485 / 100μlE45R28069N-AF488$485 / 100μlE45R28069N-AF514$485 / 100μlE45R28069N-AF532$485 / 100μlE45R28069N-AF555$485 / 100μlE45R28069N-AF568$485 / 100μlE45R28069N-AF405S$485 / 100μlE45R28069N-AF405L$485 / 100μlE45R28069N-AF546$485 / 100μlE45R28069N-AF594$485 / 100μlE45R28069N-AF610$485 / 100μlE45R28069N-AF635$485 / 100μlE45R28069N-AF647$485 / 100μlE45R28069N-AF680$485 / 100μlE45R28069N-AF700$485 / 100μlE45R28069N-AF750$485 / 100μlE45R28069N-AF790$485 / 100μlE45R28069N-APC$485 / 100μlE45R28069N-PE$485 / 100μlE45R28069N-Cy3$485 / 100μlE45R28069N-Cy5$485 / 100μlE45R28069N-Cy5.5$485 / 100μlE45R28069N-Cy7$485 / 100μlE45R28069N-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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