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Chk2 Rabbit pAb

E45R24663NDatasheetCOAMSDS
Human, Mouse, Rat
WB (Human gallbladder cancer, HCC827, Homo sapiens, Mus musculus, Rattus norvegicus)
O96017
$409/ 100 µl
Quantity
Total: $409

Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.

Product Information

Cite ID#EN5505429
TypePolyclonal Antibodies
HostRabbit
Positive controlJurkat, Mouse liver, Rat thymus
IsotypeIgG
SummaryIn response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for this gene.
FormLiquid
Storage BufferBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Price409$
ImmunogenRecombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human Chk2 (NP_009125.1).
PurificationAffinity purification
Gene ID11200
Storage/StabilityStore at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
DilutionWB 1:500 - 1:2000
IF 1:50 - 1:200

All Names

AlternameCDS1; CHK2; HuCds1; LFS2; PP1425; RAD53; hCds1; CHEK2; Chk2
📄Datasheet
Full product datasheet (PDF)✅Certificate of Analysis
Certificate of Analysis (PDF)🧪MSDS
Material safety data sheet (PDF)

Conjugated Antibody

This product is also available conjugated. Format: E45R24663N-Conjugate. Price: $485 / Size: 100μl.

E45R24663N-FITC$485 / 100μlE45R24663N-Biotin$485 / 100μlE45R24663N-HRP$485 / 100μlE45R24663N-AP$485 / 100μlE45R24663N-AF350$485 / 100μlE45R24663N-AF405M$485 / 100μlE45R24663N-AF488$485 / 100μlE45R24663N-AF514$485 / 100μlE45R24663N-AF532$485 / 100μlE45R24663N-AF555$485 / 100μlE45R24663N-AF568$485 / 100μlE45R24663N-AF405S$485 / 100μlE45R24663N-AF405L$485 / 100μlE45R24663N-AF546$485 / 100μlE45R24663N-AF594$485 / 100μlE45R24663N-AF610$485 / 100μlE45R24663N-AF635$485 / 100μlE45R24663N-AF647$485 / 100μlE45R24663N-AF680$485 / 100μlE45R24663N-AF700$485 / 100μlE45R24663N-AF750$485 / 100μlE45R24663N-AF790$485 / 100μlE45R24663N-APC$485 / 100μlE45R24663N-PE$485 / 100μlE45R24663N-Cy3$485 / 100μlE45R24663N-Cy5$485 / 100μlE45R24663N-Cy5.5$485 / 100μlE45R24663N-Cy7$485 / 100μlE45R24663N-PE-Cy5$485 / 100μl

Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.

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Chk2 Rabbit pAb | EnoGene Biotech Co. Ltd