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TBC1D4 Rabbit pAb
Mouse, Rat
$409/ 100 µl
QuantityTotal: $409
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Cite ID#EN5505839
TypePolyclonal Antibodies
HostRabbit
Positive controlRat skeletal muscle
IsotypeIgG
SummaryThis gene is a member of the Tre-2/BUB2/CDC16 domain family. The protein encoded by this gene is a Rab-GTPase-activating protein, and contains two phopshotyrosine-binding domains (PTB1 and PTB2), a calmodulin-binding domain (CBD), a Rab-GTPase domain, and multiple AKT phosphomotifs. This protein is thought to play an important role in glucose homeostasis by regulating the insulin-dependent trafficking of the glucose transporter 4 (GLUT4), important for removing glucose from the bloodstream into skeletal muscle and fat tissues. Reduced expression of this gene results in an increase in GLUT4 levels at the plasma membrane, suggesting that this protein is important in intracellular retention of GLUT4 under basal conditions. When exposed to insulin, this protein is phosphorylated, dissociates from GLUT4 vesicles, resulting in increased GLUT4 at the cell surface, and enhanced glucose transport. Phosphorylation of this protein by AKT is required for proper translocation of GLUT4 to the cell surface. Individuals homozygous for a mutation in this gene are at higher risk for type 2 diabetes and have higher levels of circulating glucose and insulin levels after glucose ingestion. Alternative splicing results in multiple transcript variants encoding different isoforms.
FormLiquid
Storage BufferBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Price409$
ImmunogenRecombinant protein of human TBC1D4.
PurificationAffinity purification
Gene ID9882
Storage/StabilityStore at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
DilutionWB 1:500 - 1:2000
IF 1:50 - 1:200
IF 1:50 - 1:200
All Names
AlternameAS160; NIDDM5; TBC1D4
Conjugated Antibody
This product is also available conjugated. Format: E45R24312N-Conjugate. Price: $485 / Size: 100μl.
E45R24312N-FITC$485 / 100μlE45R24312N-Biotin$485 / 100μlE45R24312N-HRP$485 / 100μlE45R24312N-AP$485 / 100μlE45R24312N-AF350$485 / 100μlE45R24312N-AF405M$485 / 100μlE45R24312N-AF488$485 / 100μlE45R24312N-AF514$485 / 100μlE45R24312N-AF532$485 / 100μlE45R24312N-AF555$485 / 100μlE45R24312N-AF568$485 / 100μlE45R24312N-AF405S$485 / 100μlE45R24312N-AF405L$485 / 100μlE45R24312N-AF546$485 / 100μlE45R24312N-AF594$485 / 100μlE45R24312N-AF610$485 / 100μlE45R24312N-AF635$485 / 100μlE45R24312N-AF647$485 / 100μlE45R24312N-AF680$485 / 100μlE45R24312N-AF700$485 / 100μlE45R24312N-AF750$485 / 100μlE45R24312N-AF790$485 / 100μlE45R24312N-APC$485 / 100μlE45R24312N-PE$485 / 100μlE45R24312N-Cy3$485 / 100μlE45R24312N-Cy5$485 / 100μlE45R24312N-Cy5.5$485 / 100μlE45R24312N-Cy7$485 / 100μlE45R24312N-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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