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SLC4A1 Rabbit pAb
Human, Mouse, Rat
$409/ 100 µl
QuantityTotal: $409
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Cite ID#EN5506274
TypePolyclonal Antibodies
HostRabbit
Positive controlU-87MG, K-562, mouse heart, mouse brain, rat liver
IsotypeIgG
SummaryThe protein encoded by this gene is part of the anion exchanger (AE) family and is expressed in the erythrocyte plasma membrane, where it functions as a chloride/bicarbonate exchanger involved in carbon dioxide transport from tissues to lungs. The protein comprises two domains that are structurally and functionally distinct. The N-terminal 40kDa domain is located in the cytoplasm and acts as an attachment site for the red cell skeleton by binding ankyrin. The glycosylated C-terminal membrane-associated domain contains 12-14 membrane spanning segments and carries out the stilbene disulphonate-sensitive exchange transport of anions. The cytoplasmic tail at the extreme C-terminus of the membrane domain binds carbonic anhydrase II. The encoded protein associates with the red cell membrane protein glycophorin A and this association promotes the correct folding and translocation of the exchanger. This protein is predominantly dimeric but forms tetramers in the presence of ankyrin. Many mutations in this gene are known in man, and these mutations can lead to two types of disease: destabilization of red cell membrane leading to hereditary spherocytosis, and defective kidney acid secretion leading to distal renal tubular acidosis. Other mutations that do not give rise to disease result in novel blood group antigens, which form the Diego blood group system.One null mutation in this gene is known, resulting in very severe anemia and nephrocalcinosis.
FormLiquid
Storage BufferBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Price409$
ImmunogenRecombinant fusion protein containing a sequence corresponding to amino acids 1-353 of human SLC4A1 (NP_000333.1).
PurificationAffinity purification
Gene ID6521
Storage/StabilityStore at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
DilutionWB 1:500 - 1:2000
IF 1:50 - 1:200
IF 1:50 - 1:200
All Names
AlternameDI; FR; SW; WD; WR; AE1; CHC; SAO; WD1; BND3; EPB3; SPH4; CD233; EMPB3; RTA1A; SLC4A1
Conjugated Antibody
This product is also available conjugated. Format: E45R23690N-Conjugate. Price: $485 / Size: 100μl.
E45R23690N-FITC$485 / 100μlE45R23690N-Biotin$485 / 100μlE45R23690N-HRP$485 / 100μlE45R23690N-AP$485 / 100μlE45R23690N-AF350$485 / 100μlE45R23690N-AF405M$485 / 100μlE45R23690N-AF488$485 / 100μlE45R23690N-AF514$485 / 100μlE45R23690N-AF532$485 / 100μlE45R23690N-AF555$485 / 100μlE45R23690N-AF568$485 / 100μlE45R23690N-AF405S$485 / 100μlE45R23690N-AF405L$485 / 100μlE45R23690N-AF546$485 / 100μlE45R23690N-AF594$485 / 100μlE45R23690N-AF610$485 / 100μlE45R23690N-AF635$485 / 100μlE45R23690N-AF647$485 / 100μlE45R23690N-AF680$485 / 100μlE45R23690N-AF700$485 / 100μlE45R23690N-AF750$485 / 100μlE45R23690N-AF790$485 / 100μlE45R23690N-APC$485 / 100μlE45R23690N-PE$485 / 100μlE45R23690N-Cy3$485 / 100μlE45R23690N-Cy5$485 / 100μlE45R23690N-Cy5.5$485 / 100μlE45R23690N-Cy7$485 / 100μlE45R23690N-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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