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TPO-R/CD110/c-Mpl Rabbit pAb

E45R23303NDatasheetCOAMSDS
Human, Mouse, Rat
P40238
$409/ 100 µl
Quantity
Total: $409

Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.

Product Information

Cite ID#EN5506527
TypePolyclonal Antibodies
HostRabbit
Positive controlMouse heart
IsotypeIgG
SummaryIn 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated.
FormLiquid
Storage BufferBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Price409$
ImmunogenRecombinant Protein of human TPO-R/CD110/c-TPO-R/CD110/c-Mpl
PurificationAffinity purification
Gene ID4352
Storage/StabilityStore at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
DilutionWB 1:500 - 1:2000
IF 1:50 - 1:200

All Names

AlternameMPL; C-MPL; CD110; MPLV; THCYT2; TPOR
📄Datasheet
Full product datasheet (PDF)✅Certificate of Analysis
Certificate of Analysis (PDF)🧪MSDS
Material safety data sheet (PDF)

Conjugated Antibody

This product is also available conjugated. Format: E45R23303N-Conjugate. Price: $485 / Size: 100μl.

E45R23303N-FITC$485 / 100μlE45R23303N-Biotin$485 / 100μlE45R23303N-HRP$485 / 100μlE45R23303N-AP$485 / 100μlE45R23303N-AF350$485 / 100μlE45R23303N-AF405M$485 / 100μlE45R23303N-AF488$485 / 100μlE45R23303N-AF514$485 / 100μlE45R23303N-AF532$485 / 100μlE45R23303N-AF555$485 / 100μlE45R23303N-AF568$485 / 100μlE45R23303N-AF405S$485 / 100μlE45R23303N-AF405L$485 / 100μlE45R23303N-AF546$485 / 100μlE45R23303N-AF594$485 / 100μlE45R23303N-AF610$485 / 100μlE45R23303N-AF635$485 / 100μlE45R23303N-AF647$485 / 100μlE45R23303N-AF680$485 / 100μlE45R23303N-AF700$485 / 100μlE45R23303N-AF750$485 / 100μlE45R23303N-AF790$485 / 100μlE45R23303N-APC$485 / 100μlE45R23303N-PE$485 / 100μlE45R23303N-Cy3$485 / 100μlE45R23303N-Cy5$485 / 100μlE45R23303N-Cy5.5$485 / 100μlE45R23303N-Cy7$485 / 100μlE45R23303N-PE-Cy5$485 / 100μl

Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.

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TPO-R/CD110/c-Mpl Rabbit pAb | EnoGene Biotech Co. Ltd