Product Information
Cite ID#EN5516224
TypePolyclonal Antibodies
HostRabbit
Positive controlU-87MG, HeLa, DU145, Mouse spleen, Rat testis
IsotypeIgG
SummaryDeubiquitinase that antagonizes the anaphase-promoting complex (APC/C during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2, thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2. Plays an important role in the regulation of DNA replication by stabilizing the licensing factor CDT1.
FormLiquid
Storage BufferBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.