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ROBO3 Rabbit pAb
Human
$409/ 100 µl
QuantityTotal: $409
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Cite ID#EN5509308
TypePolyclonal Antibodies
HostRabbit
Positive controlJurkat, SP2/0, SGC-7901
IsotypeIgG
SummaryThis gene is a member of the Roundabout (ROBO) gene family that controls neurite outgrowth, growth cone guidance, and axon fasciculation. ROBO proteins are a subfamily of the immunoglobulin transmembrane receptor superfamily. SLIT proteins 1-3, a family of secreted chemorepellants, are ligands for ROBO proteins and SLIT/ROBO interactions regulate myogenesis, leukocyte migration, kidney morphogenesis, angiogenesis, and vasculogenesis in addition to neurogenesis. This gene, ROBO3, has a putative extracellular domain with five immunoglobulin (Ig)-like loops and three fibronectin (Fn) type III motifs, a transmembrane segment, and a cytoplasmic tail with three conserved signaling motifs: CC0, CC2, and CC3 (CC for conserved cytoplasmic). Unlike other ROBO family members, ROBO3 lacks motif CC1. The ROBO3 gene regulates axonal navigation at the ventral midline of the neural tube. In mouse, loss of Robo3 results in a complete failure of commissural axons to cross the midline throughout the spinal cord and the hindbrain. Mutations ROBO3 result in horizontal gaze palsy with progressive scoliosis (HGPPS); an autosomal recessive disorder characterized by congenital absence of horizontal gaze, progressive scoliosis, and failure of the corticospinal and somatosensory axon tracts to cross the midline in the medulla. Alternative transcript variants have been described but have not been experimentally validated.
FormLiquid
Storage BufferBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Price409$
ImmunogenRecombinant fusion protein containing a sequence corresponding to amino acids 1-147 of human ROBO3 (NP_071765.2).
PurificationAffinity purification
Gene ID64221
Storage/StabilityStore at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
DilutionWB 1:500 - 1:2000
All Names
AlternameROBO3; HGPPS; HGPS; RBIG1; RIG1
Conjugated Antibody
This product is also available conjugated. Format: E45R21476N-Conjugate. Price: $485 / Size: 100μl.
E45R21476N-FITC$485 / 100μlE45R21476N-Biotin$485 / 100μlE45R21476N-HRP$485 / 100μlE45R21476N-AP$485 / 100μlE45R21476N-AF350$485 / 100μlE45R21476N-AF405M$485 / 100μlE45R21476N-AF488$485 / 100μlE45R21476N-AF514$485 / 100μlE45R21476N-AF532$485 / 100μlE45R21476N-AF555$485 / 100μlE45R21476N-AF568$485 / 100μlE45R21476N-AF405S$485 / 100μlE45R21476N-AF405L$485 / 100μlE45R21476N-AF546$485 / 100μlE45R21476N-AF594$485 / 100μlE45R21476N-AF610$485 / 100μlE45R21476N-AF635$485 / 100μlE45R21476N-AF647$485 / 100μlE45R21476N-AF680$485 / 100μlE45R21476N-AF700$485 / 100μlE45R21476N-AF750$485 / 100μlE45R21476N-AF790$485 / 100μlE45R21476N-APC$485 / 100μlE45R21476N-PE$485 / 100μlE45R21476N-Cy3$485 / 100μlE45R21476N-Cy5$485 / 100μlE45R21476N-Cy5.5$485 / 100μlE45R21476N-Cy7$485 / 100μlE45R21476N-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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