Product Information
Cite ID#EN5509314
TypePolyclonal Antibodies
HostRabbit
Positive controlU-87MG, OVCAR3, HT-1080, Mouse kidney, Rat testis
IsotypeIgG
SummaryThis gene is a member of the HERC family of ubiquitin ligases and encodes a protein with a HECT domain and five RCC1 repeats. Pro-inflammatory cytokines upregulate expression of this gene in endothelial cells. The protein localizes to the cytoplasm and perinuclear region and functions as an interferon-induced E3 protein ligase that mediates ISGylation of protein targets. The gene lies in a cluster of HERC family genes on chromosome 4.
FormLiquid
Storage BufferBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.