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MUL1 Rabbit pAb
Human, Mouse
$409/ 100 µl
QuantityTotal: $409
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Cite ID#EN5516049
TypePolyclonal Antibodies
HostRabbit
Positive controlA-375, Mouse liver
IsotypeIgG
SummaryExhibits weak E3 ubiquitin-protein ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. Can ubiquitinate AKT1 preferentially at 'Lys-284' involving 'Lys-48'-linked polyubiquitination and seems to be involved in regulation of Akt signaling by targeting phosphorylated Akt to proteosomal degradation. Mediates polyubiquitination of cytoplasmic TP53 at 'Lys-24' which targets TP53 for proteasomal degradation, thus reducing TP53 levels in the cytoplasm and mitochondrion. Proposed to preferentially act as a SUMO E3 ligase at physiological concentrations. Plays a role in the control of mitochondrial morphology by promoting mitochondrial fragmentation, and influences mitochondrial localization. Likely to promote mitochondrial fission through negatively regulating the mitochondrial fusion proteins MFN1 and MFN2, acting in a pathway that is parallel to the PRKN/PINK1 regulatory pathway. May also be involved in the sumoylation of the membrane fission protein DNM1L. Inhibits cell growth. When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis. Involved in the modulation of innate immune defense against viruses by inhibiting DDX58-dependent antiviral response. Can mediate DDX58 sumoylation and disrupt its polyubiquitination.
FormLiquid
Storage BufferBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Price409$
ImmunogenRecombinant fusion protein containing a sequence corresponding to amino acids 1-352 of human MUL1 (NP_078820.2).
PurificationAffinity purification
Gene ID79594
Storage/StabilityStore at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
DilutionWB 1:1000 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200
IHC 1:50 - 1:200
IF 1:50 - 1:200
All Names
AlternameC1orf166; GIDE; MAPL; MULAN; RNF218; MUL1
Conjugated Antibody
This product is also available conjugated. Format: E45R19722N-Conjugate. Price: $485 / Size: 100μl.
E45R19722N-FITC$485 / 100μlE45R19722N-Biotin$485 / 100μlE45R19722N-HRP$485 / 100μlE45R19722N-AP$485 / 100μlE45R19722N-AF350$485 / 100μlE45R19722N-AF405M$485 / 100μlE45R19722N-AF488$485 / 100μlE45R19722N-AF514$485 / 100μlE45R19722N-AF532$485 / 100μlE45R19722N-AF555$485 / 100μlE45R19722N-AF568$485 / 100μlE45R19722N-AF405S$485 / 100μlE45R19722N-AF405L$485 / 100μlE45R19722N-AF546$485 / 100μlE45R19722N-AF594$485 / 100μlE45R19722N-AF610$485 / 100μlE45R19722N-AF635$485 / 100μlE45R19722N-AF647$485 / 100μlE45R19722N-AF680$485 / 100μlE45R19722N-AF700$485 / 100μlE45R19722N-AF750$485 / 100μlE45R19722N-AF790$485 / 100μlE45R19722N-APC$485 / 100μlE45R19722N-PE$485 / 100μlE45R19722N-Cy3$485 / 100μlE45R19722N-Cy5$485 / 100μlE45R19722N-Cy5.5$485 / 100μlE45R19722N-Cy7$485 / 100μlE45R19722N-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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