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SMN2 Rabbit pAb
Human, Mouse, Rat
$409/ 100 µl
QuantityTotal: $409
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Cite ID#EN5505528
TypePolyclonal Antibodies
HostRabbit
Positive controlJurkat, 293T, MCF7, Mouse liver
IsotypeIgG
SummaryThis gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The telomeric and centromeric copies of this gene are nearly identical and encode the same protein. While mutations in the telomeric copy are associated with spinal muscular atrophy, mutations in this gene, the centromeric copy, do not lead to disease. The critical sequence difference between the two genes is a single nucleotide in exon 7, which is thought to be an exon splice enhancer. Note that the nine exons of both the telomeric and centromeric copies are designated historically as exon 1, 2a, 2b, and 3-8. It is thought that gene conversion events may involve the two genes, leading to varying copy numbers of each gene. The full length protein encoded by this gene localizes to both the cytoplasm and the nucleus. Within the nucleus, the protein localizes to subnuclear bodies called gems which are found near coiled bodies containing high concentrations of small ribonucleoproteins (snRNPs). This protein forms heteromeric complexes with proteins such as SIP1 and GEMIN4, and also interacts with several proteins known to be involved in the biogenesis of snRNPs, such as hnRNP U protein and the small nucleolar RNA binding protein. Four transcript variants encoding distinct isoforms have been described.
FormLiquid
Storage BufferBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Price409$
ImmunogenRecombinant fusion protein containing a sequence corresponding to amino acids 1-197 of human SMN2 (NP_059107.1).
PurificationAffinity purification
Gene ID6607
Storage/StabilityStore at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
DilutionWB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200
IHC 1:50 - 1:200
IF 1:50 - 1:200
All Names
AlternameSMN2; BCD541; C-BCD541; GEMIN1; SMNC; TDRD16B
Conjugated Antibody
This product is also available conjugated. Format: E45R19147N-Conjugate. Price: $485 / Size: 100μl.
E45R19147N-FITC$485 / 100μlE45R19147N-Biotin$485 / 100μlE45R19147N-HRP$485 / 100μlE45R19147N-AP$485 / 100μlE45R19147N-AF350$485 / 100μlE45R19147N-AF405M$485 / 100μlE45R19147N-AF488$485 / 100μlE45R19147N-AF514$485 / 100μlE45R19147N-AF532$485 / 100μlE45R19147N-AF555$485 / 100μlE45R19147N-AF568$485 / 100μlE45R19147N-AF405S$485 / 100μlE45R19147N-AF405L$485 / 100μlE45R19147N-AF546$485 / 100μlE45R19147N-AF594$485 / 100μlE45R19147N-AF610$485 / 100μlE45R19147N-AF635$485 / 100μlE45R19147N-AF647$485 / 100μlE45R19147N-AF680$485 / 100μlE45R19147N-AF700$485 / 100μlE45R19147N-AF750$485 / 100μlE45R19147N-AF790$485 / 100μlE45R19147N-APC$485 / 100μlE45R19147N-PE$485 / 100μlE45R19147N-Cy3$485 / 100μlE45R19147N-Cy5$485 / 100μlE45R19147N-Cy5.5$485 / 100μlE45R19147N-Cy7$485 / 100μlE45R19147N-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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