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DTL Rabbit pAb

E45R18829NDatasheetCOAMSDS
Mouse, Rat
Q9NZJ0
$409/ 100 µl
Quantity
Total: $409

Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.

Product Information

Cite ID#EN5507404
TypePolyclonal Antibodies
HostRabbit
Positive controlMouse testis, Mouse liver, Rat brain
IsotypeIgG
SummarySubstrate-specific adapter of a DCX (DDB1-CUL4-X-box E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL complex, also named CRL4(CDT2 complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1, FBH1, KMT5A and SDE2. CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1 degradation during S phase or following UV irradiation is essential to control replication licensing. KMT5A degradation is also important for a proper regulation of mechanisms such as TGF-beta signaling, cell cycle progression, DNA repair and cell migration. Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis. The DDB1-CUL4A-DTL E3 ligase complex regulates the circadian clock function by mediating the ubiquitination and degradation of CRY1.
FormLiquid
Storage BufferBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Price409$
ImmunogenRecombinant fusion protein containing a sequence corresponding to amino acids 541-730 of human DTL (NP_057532.3).
PurificationAffinity purification
Gene ID51514
Storage/StabilityStore at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
DilutionWB 1:500 - 1:2000

All Names

AlternameDTL; CDT2; DCAF2; L2DTL; RAMP
📄Datasheet
Full product datasheet (PDF)✅Certificate of Analysis
Certificate of Analysis (PDF)🧪MSDS
Material safety data sheet (PDF)

Conjugated Antibody

This product is also available conjugated. Format: E45R18829N-Conjugate. Price: $485 / Size: 100μl.

E45R18829N-FITC$485 / 100μlE45R18829N-Biotin$485 / 100μlE45R18829N-HRP$485 / 100μlE45R18829N-AP$485 / 100μlE45R18829N-AF350$485 / 100μlE45R18829N-AF405M$485 / 100μlE45R18829N-AF488$485 / 100μlE45R18829N-AF514$485 / 100μlE45R18829N-AF532$485 / 100μlE45R18829N-AF555$485 / 100μlE45R18829N-AF568$485 / 100μlE45R18829N-AF405S$485 / 100μlE45R18829N-AF405L$485 / 100μlE45R18829N-AF546$485 / 100μlE45R18829N-AF594$485 / 100μlE45R18829N-AF610$485 / 100μlE45R18829N-AF635$485 / 100μlE45R18829N-AF647$485 / 100μlE45R18829N-AF680$485 / 100μlE45R18829N-AF700$485 / 100μlE45R18829N-AF750$485 / 100μlE45R18829N-AF790$485 / 100μlE45R18829N-APC$485 / 100μlE45R18829N-PE$485 / 100μlE45R18829N-Cy3$485 / 100μlE45R18829N-Cy5$485 / 100μlE45R18829N-Cy5.5$485 / 100μlE45R18829N-Cy7$485 / 100μlE45R18829N-PE-Cy5$485 / 100μl

Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.

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DTL Rabbit pAb | EnoGene Biotech Co. Ltd