Product Information
Cite ID#EN5507002
TypePolyclonal Antibodies
HostRabbit
Positive controlRaji, HeLa, HepG2, 293T, DU145, Mouse brain, Rat brain
IsotypeIgG
SummaryGuanine nucleotide exchange factor (GEF, which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i-alpha protein, possibly leading to release G(i-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i-alpha-GDP complex (By similarity. Also acts as an activator for G(q-alpha (GNAQ protein by enhancing the G(q-coupled receptor-mediated ERK activation.
FormLiquid
Storage BufferBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.