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USP13 Rabbit pAb
Human, Mouse, Rat
$409/ 100 µl
QuantityTotal: $409
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Cite ID#EN5506938
TypePolyclonal Antibodies
HostRabbit
Positive controlMouse heart, Mouse brain, Rat heart, Rat brain
IsotypeIgG
SummaryDeubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autophagy and endoplasmic reticulum-associated degradation (ERAD. Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. Also deubiquitinates USP10, an essential regulator of p53/TP53 stability. In turn, PIK3C3/VPS34-containing complexes regulate USP13 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Recruited by nuclear UFD1 and mediates deubiquitination of SKP2, thereby regulating endoplasmic reticulum-associated degradation (ERAD. Also regulates ERAD through the deubiquitination of UBL4A a component of the BAG6/BAT3 complex. Mediates stabilization of SIAH2 independently of deubiquitinase activity: binds ubiquitinated SIAH2 and acts by impairing SIAH2 autoubiquitination. Has a weak deubiquitinase activity in vitro and preferentially cleaves 'Lys-63'-linked polyubiquitin chains. In contrast to USP5, it is not able to mediate unanchored polyubiquitin disassembly. Able to cleave ISG15 in vitro; however, additional experiments are required to confirm such data.
FormLiquid
Storage BufferBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Price409$
ImmunogenRecombinant fusion protein containing a sequence corresponding to amino acids 90-200 of human USP13 (NP_003931.2).
PurificationAffinity purification
Gene ID8975
Storage/StabilityStore at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
DilutionWB 1:1000 - 1:2000
IHC 1:50 - 1:200
IHC 1:50 - 1:200
All Names
AlternameUSP13; ISOT3; IsoT-3
Conjugated Antibody
This product is also available conjugated. Format: E45R17888N-Conjugate. Price: $485 / Size: 100μl.
E45R17888N-FITC$485 / 100μlE45R17888N-Biotin$485 / 100μlE45R17888N-HRP$485 / 100μlE45R17888N-AP$485 / 100μlE45R17888N-AF350$485 / 100μlE45R17888N-AF405M$485 / 100μlE45R17888N-AF488$485 / 100μlE45R17888N-AF514$485 / 100μlE45R17888N-AF532$485 / 100μlE45R17888N-AF555$485 / 100μlE45R17888N-AF568$485 / 100μlE45R17888N-AF405S$485 / 100μlE45R17888N-AF405L$485 / 100μlE45R17888N-AF546$485 / 100μlE45R17888N-AF594$485 / 100μlE45R17888N-AF610$485 / 100μlE45R17888N-AF635$485 / 100μlE45R17888N-AF647$485 / 100μlE45R17888N-AF680$485 / 100μlE45R17888N-AF700$485 / 100μlE45R17888N-AF750$485 / 100μlE45R17888N-AF790$485 / 100μlE45R17888N-APC$485 / 100μlE45R17888N-PE$485 / 100μlE45R17888N-Cy3$485 / 100μlE45R17888N-Cy5$485 / 100μlE45R17888N-Cy5.5$485 / 100μlE45R17888N-Cy7$485 / 100μlE45R17888N-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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