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RPA70/RPA1 Rabbit pAb
Human
$409/ 100 µl
QuantityTotal: $409
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Cite ID#EN5506804
TypePolyclonal Antibodies
HostRabbit
Positive controlU-87MG, HeLa, 293T, A-549
IsotypeIgG
SummaryAs part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism (PubMed:27723720, PubMed:27723717). In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response (PubMed:24332808). It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage (PubMed:17765923). Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair (PubMed:7697716). Plays also a role in base excision repair (BER) probably through interaction with UNG (PubMed:9765279). Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance (PubMed:17959650). The aRPA may not promote efficient priming by DNA polymerase alpha but could support DNA synthesis by polymerase delta in presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange.
FormLiquid
Storage BufferBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Price409$
ImmunogenRecombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human RPA70/RPA70/RPA1 (NP_002936.1).
PurificationAffinity purification
Gene ID6117
Storage/StabilityStore at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
DilutionWB 1:500 - 1:2000
IHC 1:50 - 1:100
IHC 1:50 - 1:100
All Names
AlternameRPA1; HSSB; MST075; REPA1; RF-A; RP-A; RPA70
Conjugated Antibody
This product is also available conjugated. Format: E45R17572N-Conjugate. Price: $485 / Size: 100μl.
E45R17572N-FITC$485 / 100μlE45R17572N-Biotin$485 / 100μlE45R17572N-HRP$485 / 100μlE45R17572N-AP$485 / 100μlE45R17572N-AF350$485 / 100μlE45R17572N-AF405M$485 / 100μlE45R17572N-AF488$485 / 100μlE45R17572N-AF514$485 / 100μlE45R17572N-AF532$485 / 100μlE45R17572N-AF555$485 / 100μlE45R17572N-AF568$485 / 100μlE45R17572N-AF405S$485 / 100μlE45R17572N-AF405L$485 / 100μlE45R17572N-AF546$485 / 100μlE45R17572N-AF594$485 / 100μlE45R17572N-AF610$485 / 100μlE45R17572N-AF635$485 / 100μlE45R17572N-AF647$485 / 100μlE45R17572N-AF680$485 / 100μlE45R17572N-AF700$485 / 100μlE45R17572N-AF750$485 / 100μlE45R17572N-AF790$485 / 100μlE45R17572N-APC$485 / 100μlE45R17572N-PE$485 / 100μlE45R17572N-Cy3$485 / 100μlE45R17572N-Cy5$485 / 100μlE45R17572N-Cy5.5$485 / 100μlE45R17572N-Cy7$485 / 100μlE45R17572N-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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