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PPP1R12A Rabbit pAb
Human, Mouse, Rat
$409/ 100 µl
QuantityTotal: $409
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Cite ID#EN5506718
TypePolyclonal Antibodies
HostRabbit
Positive controlU-87MG, LO2, Jurkat, HeLa
IsotypeIgG
SummaryMyosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC. Thus, Rho appears to inhibit myosin phosphatase through the action of Rho-kinase. Several transcript variants encoding different isoforms have been found for this gene.
FormLiquid
Storage BufferBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Price409$
ImmunogenRecombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human PPP1R12A (NP_002471.1).
PurificationAffinity purification
Gene ID4659
Storage/StabilityStore at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
DilutionWB 1:500 - 1:2000
IF 1:50 - 1:200
IP 1:50 - 1:100
IF 1:50 - 1:200
IP 1:50 - 1:100
All Names
AlternamePPP1R12A; M130; MBS; MYPT1; MYPT1
Conjugated Antibody
This product is also available conjugated. Format: E45R17482N-Conjugate. Price: $485 / Size: 100μl.
E45R17482N-FITC$485 / 100μlE45R17482N-Biotin$485 / 100μlE45R17482N-HRP$485 / 100μlE45R17482N-AP$485 / 100μlE45R17482N-AF350$485 / 100μlE45R17482N-AF405M$485 / 100μlE45R17482N-AF488$485 / 100μlE45R17482N-AF514$485 / 100μlE45R17482N-AF532$485 / 100μlE45R17482N-AF555$485 / 100μlE45R17482N-AF568$485 / 100μlE45R17482N-AF405S$485 / 100μlE45R17482N-AF405L$485 / 100μlE45R17482N-AF546$485 / 100μlE45R17482N-AF594$485 / 100μlE45R17482N-AF610$485 / 100μlE45R17482N-AF635$485 / 100μlE45R17482N-AF647$485 / 100μlE45R17482N-AF680$485 / 100μlE45R17482N-AF700$485 / 100μlE45R17482N-AF750$485 / 100μlE45R17482N-AF790$485 / 100μlE45R17482N-APC$485 / 100μlE45R17482N-PE$485 / 100μlE45R17482N-Cy3$485 / 100μlE45R17482N-Cy5$485 / 100μlE45R17482N-Cy5.5$485 / 100μlE45R17482N-Cy7$485 / 100μlE45R17482N-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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