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MAP3K5 Rabbit pAb
Datasheet   

  • Catalog Number:

    E45R17395N

  • Amount:

    100 µl

  • Cite ID#:

    EN5506737

  • Price:

    409$

  • Type:

    Polyclonal Antibodies

  • Host:

    Rabbit

  • Reactivity:

    Human, Mouse

  • Immunogen:

    Recombinant fusion protein containing a sequence corresponding to amino acids 1175-1374 of human MAP3K5 (NP_005914.1).

  • Positive control:

    HL-60, Mouse liver

  • Isotype:

    IgG

  • Purification:

    Affinity purification

  • Gene ID:

    4217

  • Swiss-Prot No.:

    Q99683

  • Summary:

    Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK.

  • Form:

    Liquid

  • Storage/Stability:

    Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

  • Storage Buffer:

    Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

  • Dilution:

    WB 1:500 - 1:2000

  • Altername:

    MAP3K5; ASK1; MAPKKK5; MEKK5

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MAP3K5 Rabbit pAb | EnoGene Biotech Co. Ltd