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Phospho-AKT1-S473 Rabbit mAb
Human, Mouse, Rat
IHC (Human lung cancer cells)
WB (Human lung cancer cells, Homo sapiens, Mus musculus, Rattus norvegicus)
WB (Human lung cancer cells, Homo sapiens, Mus musculus, Rattus norvegicus)
$614/ 100 µl
QuantityTotal: $614
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Product Information
Cite ID#EN5520353
TypePhosphorylated Antibodies
HostRabbit
Positive controlJurkat, NIH/3T3, C6
IsotypeIgG
SummaryThe serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene.
FormLiquid
Storage BufferBuffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Price614$
ImmunogenA phospho specific peptide corresponding to residues surrounding S473 of human AKT1
PurificationAffinity purification
Gene ID207
Storage/StabilityStore at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
DilutionWB 1:500 - 1:2000
All Names
AlternameAKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA; AKT1
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