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[KO Validated] Smad2 Rabbit mAb
$526/ 100 µl
QuantityTotal: $526
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Cite ID#EN5520260
TypeMonoclonal Antibodies
HostRabbit
Positive controlHeLa, HT-29, Jurkat, NIH/3T3, Rat lung
IsotypeIgG
SummaryThe protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]
FormLiquid
Storage BufferBuffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Price526$
ImmunogenA synthesized peptide derived from human Smad2
PurificationAffinity purification
Gene ID4087
Storage/StabilityStore at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
DilutionWB 1:500 - 1:2000
IF 1:50 - 1:200
IP 1:50 - 1:200
IF 1:50 - 1:200
IP 1:50 - 1:200
All Names
AlternameJV18; JV18-1; MADH2; MADR2; hMAD-2; hSMAD2; Smad2; SMAD2
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