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E2F1 Rabbit mAb
$458/ 100 µl
QuantityTotal: $458
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Product Information
Cite ID#EN5520231
TypeMonoclonal Antibodies
HostRabbit
Positive controlU-87MG, HT-29, HeLa, A-431, Mouse testis, Mouse brain, Rat thymus, Rat spleen
IsotypeIgG
SummaryThe protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis. [provided by RefSeq, Jul 2008]
FormLiquid
Storage BufferBuffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Price458$
ImmunogenA synthesized peptide derived from human E2F1.
PurificationAffinity purification
Gene ID1869
Storage/StabilityStore at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
DilutionWB 1:500 - 1:2000
IP 1:50 - 1:200
IP 1:50 - 1:200
All Names
AlternameE2F-1; RBAP1; RBBP3; RBP3; E2F1
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