Product Information
Cite ID#EN5520109
TypeMonoclonal Antibodies
HostRabbit
Positive controlTHP-1, Mouse spleen, Rat thymus
IsotypeIgG
SummaryThe protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.[provided by RefSeq, May 2011]
FormLiquid
Storage BufferBuffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.