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Notch1 Rabbit mAb
Human, Mouse
$458/ 100 µl
QuantityTotal: $458
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Product Information
Cite ID#EN5519983
TypeMonoclonal Antibodies
HostRabbit
Positive control293T, Jurkat, Mouse lung, Mouse brain
IsotypeIgG
SummaryThis gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor plays a role in the development of numerous cell and tissue types. Mutations in this gene are associated with aortic valve disease, Adams-Oliver syndrome, T-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, and head and neck squamous cell carcinoma. [provided by RefSeq, Jan 2016]
FormLiquid
Storage BufferBuffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Price458$
ImmunogenA synthesized peptide derived from human Notch1
PurificationAffinity purification
Gene ID4851
Storage/StabilityStore at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
DilutionWB 1:500 - 1:2000
IP 1:50 - 1:200
IP 1:50 - 1:200
All Names
AlternameAOS5; AOVD1; TAN1; hN1; NOTCH1; Activated NOTCH1; notch 1
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