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Presenilin 1 Rabbit mAb
Human, Mouse, Rat
$458/ 100 µl
QuantityTotal: $458
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Product Information
Cite ID#EN5519956
TypeMonoclonal Antibodies
HostRabbit
Positive controlA-431, Jurkat, U-251MG, Mouse testis, Mouse liver, Mouse brain, Rat brain
IsotypeIgG
SummaryAlzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008]
FormLiquid
Storage BufferBuffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Price458$
ImmunogenA synthesized peptide derived from human Presenilin 1
PurificationAffinity purification
Gene ID5663
Storage/StabilityStore at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
DilutionWB 1:500 - 1:2000
All Names
AlternameAD3; FAD; PS-1; PS1; S182; Presenilin 1; PSEN1
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