Product Information
Cite ID#EN5518497
TypeMonoclonal Antibodies
HostRabbit
Positive controlK-562, A-549, NIH/3T3, Rat lung, HeLa, HeLa whole cell protein, HeLa cytoplasm protein, HeLa nuclear protein, NIH/3T3 whole cell protein, NIH/3T3 cytoplasm protein, NIH/3T3 nuclear protein, C6 whole cell protein, C6 cytoplasm protein, C6 nuclear protein
IsotypeIgG
SummaryThe nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.
FormLiquid
Storage BufferBuffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.