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Phospho-ERBB2 (Y1127) Antibody
Datasheet   

  • Catalog Number:

    E45R05254G-1

  • Amount:

    100 µl

  • Cite ID#:

    EN5483509

  • Price:

    395$

  • Type:

    Rabbit Polyclonal Antibody

  • Host:

    Rabbit

  • Reactivity:

    H

  • Immunogen:

    This ERBB2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y1127 of human ERBB2.

  • Purification:

    Affinity chromatography purified.

  • Gene Name:

    ERBB2

  • Gene ID:

    2064

  • Swiss-Prot No.:

    P04626

  • Function:

    Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.

  • Summary:

    Tissue Location:
    Expressed in a variety of tumor tissues including primary breast tumors and tumors from small bowel, esophagus, kidney and mouth.

  • Form:

    Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by two-step phosphospecific peptide affinity purification.

  • Storage/Stability:

    For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

  • Applications:

    IF, DB, WB

  • Dilution:

    WB--1:1000
    WB--1:5000
    IF--1:100
    DB--1:500

  • Altername:

    Receptor tyrosine-protein kinase erbB-2, Metastatic lymph node gene 19 protein, MLN 19, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, Tyrosine kinase-type cell surface receptor HER2, p185erbB2, CD340, ERBB2, HER2, MLN19, NEU, NGL

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Phospho-ERBB2 (Y1127) Antibody | EnoGene Biotech Co. Ltd