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Phospho-BRCA1-S1423 Rabbit pAb
Human, Mouse, Rat
$510/ 100 µl
QuantityTotal: $510
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Cite ID#EN5505636
TypePhosphorylated Antibodies
HostRabbit
Positive controlHT-29
IsotypeIgG
SummaryThis gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified.
FormLiquid
Storage BufferBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Price510$
ImmunogenA synthetic phosphorylated peptide around S1423 of human BRCA1 (NP_009225.1).
PurificationAffinity purification
Gene ID672
Storage/StabilityStore at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
DilutionWB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200
IHC 1:50 - 1:200
IF 1:50 - 1:200
All Names
AlternameBRCA1; BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53
Conjugated Antibody
This product is also available conjugated. Format: E45R00875N-Conjugate. Price: $485 / Size: 100μl.
E45R00875N-FITC$485 / 100μlE45R00875N-Biotin$485 / 100μlE45R00875N-HRP$485 / 100μlE45R00875N-AP$485 / 100μlE45R00875N-AF350$485 / 100μlE45R00875N-AF405M$485 / 100μlE45R00875N-AF488$485 / 100μlE45R00875N-AF514$485 / 100μlE45R00875N-AF532$485 / 100μlE45R00875N-AF555$485 / 100μlE45R00875N-AF568$485 / 100μlE45R00875N-AF405S$485 / 100μlE45R00875N-AF405L$485 / 100μlE45R00875N-AF546$485 / 100μlE45R00875N-AF594$485 / 100μlE45R00875N-AF610$485 / 100μlE45R00875N-AF635$485 / 100μlE45R00875N-AF647$485 / 100μlE45R00875N-AF680$485 / 100μlE45R00875N-AF700$485 / 100μlE45R00875N-AF750$485 / 100μlE45R00875N-AF790$485 / 100μlE45R00875N-APC$485 / 100μlE45R00875N-PE$485 / 100μlE45R00875N-Cy3$485 / 100μlE45R00875N-Cy5$485 / 100μlE45R00875N-Cy5.5$485 / 100μlE45R00875N-Cy7$485 / 100μlE45R00875N-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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