Product Information
Cite ID#EN5505524
TypeMethylated Antibodies
HostRabbit
Positive controlC6
IsotypeIgG
SummaryThis gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12.
FormLiquid
Storage BufferBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
ImmunogenA synthetic monomethylated peptide around K385 of human UHRF1 (NP_001041666.1).
PurificationAffinity purification
Storage/StabilityStore at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
DilutionDB 1:500 - 1:2000
WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200
All Names
AlternameUHRF1; ICBP90; Np95; RNF106; TDRD22; hNP95; hUHRF1; huNp95