IL-18Rβ / IL-18RAcP Protein, Mouse, Recombinant (His Tag)
Datasheet
Catalog Number:
E45M52918I2-100Amount:
100 ugCite ID#:
EN5423008Price:
1047$Type:
Recombinant ProteinsResearch Field:
NeuroinflammationProtein length:
A DNA sequence encoding the mouse IL18RAP (NP_034683.1) (Met1-Glu356) was expressed with a C-terminal polyhistidine tag.Expression Host:
Baculovirus-Insect CellsSpecies:
MouseAmino acid sequence:
Met1-Glu356Tag:
C-HisMolecular Weight:
The recombinant mouse IL18RAP comprises 348 amino acids and has a predicted molecular mass of 40.1 kDa. The apparent molecular mass of the protein is approximately 44 kDa in SDS-PAGE under reducing conditions.Activity:
Measured by its binding ability in a functional ELISA.Immobilized mouse IL18RAP-His at 10 μg/ml (100 μl/well) can bind biotinylated mouse IL18 (Cat:PM53211E0), The ECof biotinylated mouse IL18 (Cat:PM53211E0) is 10.6-25.0 μg/ml.Endotoxin:
< 1.0 EU per μg of the protein as determined by the LAL method.Gene Name:
interleukin 18 receptor accessory proteinGene symbol:
IL18RAPProtein Refseq:
NP_034683.1Function:
Cytokine Proteins, Interleukin proteins, CD Molecule proteins, Receptor ProteinsSummary:
Interleukin 18 receptor accessory protein, also known as IL18RAP and CDw218b (cluster of differentiation w218b), is an accessory subunit of the heterodimeric receptor for IL18. This protein enhances the IL18 binding activity of IL18R1 (IL1RRP), a ligand-binding subunit of the IL18 receptor. The coexpression of IL18R1 and this protein is required for the activation of NF-kappaB and MAPK8 (JNK) in response to IL18. IL18RAP is required for the high-affinity binding of interleukin 18 (IL-18) to its receptor complex. IL18RAP together with IL18R1 mediates IL-18-dependent activation of NF-kappa-B and JNK. Two putative isoforms of IL18RAP were detected and the ratios and total levels of these isoforms may contribute to the etiology of coeliac disease. IL18R1 and IL18RAP polymorphisms have been found associated with diseases such as schizophrenia, HSV1 seropositivity, and atopic asthma. Analysis of IL18R1 and IL18RAP SNPs in 5 European prospective cohorts suggests that the variability of these genes are unlikely to contribute to modulate the risk of CVD in European populations.Form:
LyophilizedPurity:
> 95 % as determined by SDS-PAGE.Storage/Stability:
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.Storage Buffer:
Lyophilized from sterile 20 mM Tris, 500 mM NaCl, 10% glycerol, pH 7.4.
Please contact us for any concerns or special requirements.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the hard copy of CoA.Synonyms:
AcPL Protein, Mouse; IL-18R-beta Protein, Mouse; IL-18RAcP Protein, Mouse; IL-18Rbeta Protein, Mouse; IL-1RAcPL Protein, Mouse
Related Products
Catalog Number
- Amount:100 ug
- Price:1047$
Contact us
Categories by research area
Categories by product type
- Antibodies
- Tag antibodies
- Internal control antibodies
- Pathological (Immunohistochemistry, IHC) antibodies
- Cell Signal Transduction Research Antibodies
- Secondary Antibody
- Antibody Sampler Kits
- Recombinant Proteins
- Fluorescence Reagents
- Signal Inhibitors and Activators
- Transfection Reagent
- Cell biology kits