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Transferrin Receptor/TFRC Protein, Mouse, Recombinant (ECD, His Tag)
Datasheet   

  • Catalog Number:

    E45M52622M1-100

  • Amount:

    100 ug

  • Cite ID#:

    EN5422712

  • Price:

    1223$

  • Type:

    Recombinant Proteins

  • Protein length:

    A DNA sequence encoding the extracellular domain of mouse TFRC (Q62351) (Cys 89-Phe 763) was fused with a polyhistidine tag at the N-terminus.

  • Expression Host:

    HEK293 Cells

  • Species:

    Mouse

  • Amino acid sequence:

    Cys89-Phe763

  • Tag:

    N-His

  • Molecular Weight:

    The recombinant mouse TFRC comprises 694 amino acids and predicts a molecular mass of 78.3 kDa. The apparent molecular mass of mouse TFRC is approximately 80 kDa in SDS-PAGE under reducing conditions due to glycosylation.

  • Activity:

    At Leading Biology, the biological activity of a recombinant protein is routinely measured using a bioassay, e.g. chemotaxis or cell proliferation assay, enzyme assay, or a functional ELISA.
    When a recombinant protein is an enzyme, specific activity is derived from an enzymatic assay. Each enzyme is tested for potency by cleavage of a substrate.
    We are in the process of updating the biological activity data. If you have any questions regarding this update, please feel free to contact our technical support team.

  • Endotoxin:

    < 1.0 EU per μg of the protein as determined by the LAL method.

  • Gene Name:

    transferrin receptor

  • Gene symbol:

    TFRC

  • Swiss-Prot No.:

    Q62351

  • Function:

    CD Molecule proteins

  • Summary:

    Transferrin receptor protein 1, also known as transferrin receptor, Trfr, p9, CD71 and TFRC, is a single-pass type II membrane protein that belongs to the peptidase M28 family and M28B subfamily. TFRC / CD71 is a membrane-bound protein expressed in larger amounts in proliferating. The specific expression of TFRC can represent a diagnostic tool or a therapeutic target in solid tumours expressing this antigen. Transferrin receptor is necessary for development of erythrocytes and the nervous system. TFRC / CD71 is regulated by cellular iron levels through binding of the iron regulatory proteins, IRP1 and IRP2, to iron-responsive elements in the 3'-UTR. Up-regulated upon mitogenic stimulation. TFRC / CD71 represents a marker of malignant transformation in the pancreas that could be applied as potential diagnostic and therapeutic target.

  • Form:

    Lyophilized

  • Purity:

    > 92 % as determined by SDS-PAGE.

  • Storage/Stability:

    In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
    Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

  • Storage Buffer:

    Lyophilized from sterile 20mM Tris, 150mM NaCl, 5% Mannitol, 0.1% Tween 80, pH 7.5
    Please contact us for any concerns or special requirements.
    Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
    Please refer to the specific buffer information in the hard copy of CoA.

  • Synonyms:

    2610028K12Rik Protein, Mouse; AI195355 Protein, Mouse; AI426448 Protein, Mouse; AU015758 Protein, Mouse; CD71 Protein, Mouse; E430033M20Rik Protein, Mouse; Mtvr-1 Protein, Mouse; Mtvr1 Protein, Mouse; p90 Protein, Mouse; TFR Protein, Mouse; TFR1 Protein, Mouse; TR Protein, Mouse; Trfr Protein, Mouse

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  • Amount:100 ug
  • Price:1223$

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Transferrin Receptor/TFRC Protein, Mouse, Recombinant (ECD, His Tag) | EnoGene Biotech Co. Ltd