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CDKN2A/p16INK4a Mouse mAb
Human
$458/ 100 µl
QuantityTotal: $458
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Cite ID#EN5516822
TypeMonoclonal Antibodies
HostMouse
IsotypeIgG
SummaryThis gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene.
FormLiquid
Storage BufferBuffer, pH7.3-7.7, with 1% BSA and <0.1% Sodium azide.
Price458$
ImmunogenRecombinant protein of human CDKN2A/p16INK4a.
PurificationCell culture supernatant concentrate
Gene ID1029
Storage/StabilityStore at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
DilutionWB 1:500 - 1:2000
IHC 1:100 - 1:400
IHC 1:100 - 1:400
All Names
AlternameCDKN2A; ARF; CDK4I; CDKN2; CMM2; INK4; INK4A; MLM; MTS-1; MTS1; P14; P14ARF; P16; P16-INK4A; P16INK4; P16INK4A; P19; P19ARF; TP16
Conjugated Antibody
This product is also available conjugated. Format: E45M22058N-Conjugate. Price: $485 / Size: 100μl.
E45M22058N-FITC$485 / 100μlE45M22058N-Biotin$485 / 100μlE45M22058N-HRP$485 / 100μlE45M22058N-AP$485 / 100μlE45M22058N-AF350$485 / 100μlE45M22058N-AF405M$485 / 100μlE45M22058N-AF488$485 / 100μlE45M22058N-AF514$485 / 100μlE45M22058N-AF532$485 / 100μlE45M22058N-AF555$485 / 100μlE45M22058N-AF568$485 / 100μlE45M22058N-AF405S$485 / 100μlE45M22058N-AF405L$485 / 100μlE45M22058N-AF546$485 / 100μlE45M22058N-AF594$485 / 100μlE45M22058N-AF610$485 / 100μlE45M22058N-AF635$485 / 100μlE45M22058N-AF647$485 / 100μlE45M22058N-AF680$485 / 100μlE45M22058N-AF700$485 / 100μlE45M22058N-AF750$485 / 100μlE45M22058N-AF790$485 / 100μlE45M22058N-APC$485 / 100μlE45M22058N-PE$485 / 100μlE45M22058N-Cy3$485 / 100μlE45M22058N-Cy5$485 / 100μlE45M22058N-Cy5.5$485 / 100μlE45M22058N-Cy7$485 / 100μlE45M22058N-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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