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P Glycoprotein (ABCB1) Mouse Monoclonal Antibody [Clone 1B8]
Datasheet
Catalog Number:
E45M21475V-2Amount:
50 ulCite ID#:
EN5457630Price:
195$Type:
Mouse Monoclonal AntibodyResearch Field:
ABC transportersProduct Description:
MDR-1/ABCB1 mouse monoclonal antibody, Clone 1B8Host:
MouseReactivity:
Human, Mouse, RatImmunogen:
Full length human recombinant protein of human MDR-1/ABCB1 (NP_000918) produced in E.coli.Target:
ABCB1Clone Number:
Clone 1B8Isotype:
IgG1Purification:
Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)Gene Name:
ATP binding cassette subfamily B member 1Gene symbol:
ABCB1Gene ID:
5243Swiss-Prot No.:
P08183Pathway:
ABC transportersFunction:
Druggable Genome, ES Cell Differentiation/IPS, TransmembraneSummary:
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Feb 2017]Form:
PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.Concentration:
1 mg/mlStorage/Stability:
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.Applications:
IHC 1:200Synonyms:
ABC20; CD243; CLCS; GP170; MDR1; p-170; P-GP; PGY1
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Catalog Number
- Amount:50 ul
- Price:195$
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