TRAIL (TNFSF10) Mouse Monoclonal Antibody [Clone 9A8]
Datasheet
Catalog Number:
E45M20452V-2Amount:
50 ulCite ID#:
EN5456607Price:
195$Type:
Mouse Monoclonal AntibodyResearch Field:
Apoptosis, Cytokine-cytokine receptor interaction, Natural killer cell mediated cytotoxicityProduct Description:
TNFSF10 mouse monoclonal antibody,Clone 9A8Host:
MouseReactivity:
HumanImmunogen:
Human recombinant protein fragment corresponding to amino acids 39-281 of human TNFSF10 (NP_003801) produced in E.coli.Target:
TNFSF10Clone Number:
Clone 9A8Isotype:
IgG2aPurification:
Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)Gene Name:
tumor necrosis factor superfamily member 10Gene symbol:
TNFSF10Gene ID:
8743Swiss-Prot No.:
P50591Pathway:
Apoptosis, Cytokine-cytokine receptor interaction, Natural killer cell mediated cytotoxicityFunction:
Druggable Genome, TransmembraneSummary:
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]Form:
PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.Concentration:
1 mg/mlStorage/Stability:
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.Applications:
WB 1:500Synonyms:
Apo-2L; APO2L; CD253; TL2; TRAIL
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Catalog Number
- Amount:50 ul
- Price:195$
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