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Glucocorticoid Receptor (NR3C1) Mouse Monoclonal Antibody [Clone 2C4]
Datasheet
Catalog Number:
E45M17227V-2Amount:
50 ulCite ID#:
EN5453382Price:
195$Type:
Mouse Monoclonal AntibodyResearch Field:
Neuroactive ligand-receptor interactionProduct Description:
NR3C1 mouse monoclonal antibody, Clone 2C4Host:
MouseReactivity:
Human, Mouse, RatImmunogen:
Human recombinant protein fragment corresponding to amino acids 1-265 of human NR3C1(NP_000167) produced in E.coli.Target:
NR3C1Clone Number:
Clone 2C4Isotype:
IgG2bPurification:
Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)Gene Name:
nuclear receptor subfamily 3 group C member 1Gene symbol:
NR3C1Gene ID:
2908Swiss-Prot No.:
P04150Pathway:
Neuroactive ligand-receptor interactionFunction:
Druggable Genome, Nuclear Hormone Receptor, Transcription FactorsSummary:
This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011]Form:
PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.Concentration:
1 mg/mlStorage/Stability:
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.Applications:
WB 1:2000, IHC 1:150Synonyms:
GCCR; GCR; GCRST; GR; GRL
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Catalog Number
- Amount:50 ul
- Price:195$
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