CCM2 Mouse Monoclonal Antibody [Clone 1E9]

CCM2 Mouse Monoclonal Antibody [Clone 1E9]
Datasheet

Catalog Number:
E45M11672V-2
Amount:
50 ul
Cite ID#:
EN5447827
Price:
195$
Type:
Mouse Monoclonal Antibody
Product Description:
CCM2 mouse monoclonal antibody, Clone 1E9
Host:
Mouse
Reactivity:
Human, Mouse, Rat
Immunogen:
Full length human recombinant protein of human CCM2(NP_113631) produced in HEK293T cell.
Target:
CCM2
Clone Number:
Clone 1E9
Isotype:
IgG1
Purification:
Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Gene Name:
CCM2 scaffold protein
Gene symbol:
CCM2
Gene ID:
83605
Swiss-Prot No.:
Q9BSQ5
Summary:
This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.
Form:
PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration:
0.38 mg/ml
Storage/Stability:
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Applications:
WB 1:500~2000, IHC 1:150
Synonyms:
C7orf22; OSM; PP10187

CCM2 Mouse Monoclonal Antibody [Clone 1E9]
Datasheet