Catalog Number:
E45H38551M5Amount:
20 ugCite ID#:
EN5440983Price:
785$Type:
Recombinant ProteinsResearch Field:
Ubiquitin mediated proteolysisProduct Description:
Recombinant protein of human ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast) (UBE2D2), transcript variant 2Protein length:
Recombinant protein was produced with GoldORF clone, [GH37171V]. Click on the GoldORF clone link to view cDNA and protein sequences.Expression Host:
HEK293TSpecies:
HumanMolecular Weight:
13.5 kDaGene symbol:
UBE2D2Gene ID:
7322mRNA Refseq:
NM_181838Protein Refseq:
NP_862821Swiss-Prot No.:
P62837Chromosome location:
5q31.2Pathway:
Ubiquitin mediated proteolysisSummary:
Regulated degradation of misfolded, damaged or short-lived proteins in eukaryotes occurs via the ubiquitin (Ub)-proteasome system (UPS). An integral part of the UPS system is the ubiquitination of target proteins and covalent linkage of Ub-containing proteins to form polymeric chains, marking them as targets for 26S proteasome-mediated degradation. Ubiquitination of proteins is mediated by a cascade of enzymes which includes E1 (ubiquitin activating), E2 (ubiquitin conjugating), and E3 (ubiquitin ligases) enzymes. This gene encodes a member of the E2 enzyme family. Substrates of this enzyme include the tumor suppressor protein p53 and peroxisomal biogenesis factor 5 (PEX5). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]Form:
LiquidConcentration:
>50 ug/mL as determined by microplate BCA methodPurity:
> 80% as determined by SDS-PAGE and Coomassie blue stainingStorage/Stability:
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.Storage Buffer:
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerolSynonyms:
E2(17)KB2; PUBC1; UBC4; UBC4/5; UBCH4; UBCH5B