Presenilin 1 (PSEN1) (NM_000021) Human Recombinant Protein
Datasheet
Catalog Number:
E45H35662M5Amount:
20 ugCite ID#:
EN5438095Price:
785$Type:
Recombinant ProteinsResearch Field:
Alzheimer's disease, Neurotrophin signaling pathway, Notch signaling pathway, Wnt signaling pathwayProduct Description:
Recombinant protein of human presenilin 1 (PSEN1), transcript variant 1Protein length:
Recombinant protein was produced with GoldORF clone, [GH45985V]. Click on the GoldORF clone link to view cDNA and protein sequences.Expression Host:
HEK293TSpecies:
HumanMolecular Weight:
52.5 kDaGene symbol:
PSEN1Gene ID:
5663mRNA Refseq:
NM_000021Protein Refseq:
NP_000012Swiss-Prot No.:
P49768, A0A024R6A3Chromosome location:
14q24.2Pathway:
Alzheimer's disease, Neurotrophin signaling pathway, Notch signaling pathway, Wnt signaling pathwayFunction:
Druggable Genome, Protease, TransmembraneSummary:
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008]Form:
LiquidConcentration:
>50 ug/mL as determined by microplate BCA methodPurity:
> 80% as determined by SDS-PAGE and Coomassie blue stainingStorage/Stability:
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.Storage Buffer:
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerolSynonyms:
ACNINV3; AD3; FAD; PS-1; PS1; S182
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Catalog Number
- Amount:20 ug
- Price:785$
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