MET (NM_000245) Human Recombinant Protein
Datasheet
Catalog Number:
E45H32437E0Amount:
50 ugCite ID#:
EN5435351Price:
769$Type:
Recombinant ProteinsResearch Field:
Adherens junction, Axon guidance, Colorectal cancer, Cytokine-cytokine receptor interaction, Endocytosis, Epithelial cell signaling in Helicobacter pylori infection, Focal adhesion, Melanoma, Pathways in cancer, Renal cell carcinomaProduct Description:
Purified recombinant protein of Human met proto-oncogene (hepatocyte growth factor receptor) (MET), transcript variant 2, Thr678-Ile743, tag free, expressed in E.coli, 50ugProtein length:
A DNA sequence encoding the region(Thr678-Ile743) of METExpression Host:
E. coliSpecies:
HumanMolecular Weight:
7.3 kDaGene symbol:
METGene ID:
4233mRNA Refseq:
NM_000245Protein Refseq:
NP_000236Swiss-Prot No.:
P08581, A0A024R759Chromosome location:
7q31.2Pathway:
Adherens junction, Axon guidance, Colorectal cancer, Cytokine-cytokine receptor interaction, Endocytosis, Epithelial cell signaling in Helicobacter pylori infection, Focal adhesion, Melanoma, Pathways in cancer, Renal cell carcinomaFunction:
Druggable Genome, Protein Kinase, TransmembraneSummary:
This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers. [provided by RefSeq, May 2016]Form:
LiquidConcentration:
>50 ug/mL as determined by microplate BCA methodPurity:
> 80% as determined by SDS-PAGE and Coomassie blue stainingStorage/Stability:
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.Storage Buffer:
PBS, 10% glycerolSynonyms:
AUTS9; c-Met; DFNB97; HGFR; RCCP2
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Catalog Number
- Amount:50 ug
- Price:769$
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