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PROTAK™ K-Ras ligand-Linker Conjugate 4
$1920/ 100mg
QuantityTotal: $1920
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Product Information
CAS No.2378261-83-5
FormulaC35H51N7O8
M.W.697.82
SolubilitySoluble in DMSO
Storage/StabilityStore at -20°C
BackgroundK-Ras ligand-Linker Conjugate 4 incorporates a ligand for K-Ras recruiting moiety, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 4 can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523), which is potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells.
CREW, Andrew P., et al. MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE.
CREW, Andrew P., et al. MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE.
Price1920$
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