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PROTAK™ Pomalidomide-amido-C1-Br
$840/ 5mg
Specification
QuantityTotal: $840
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Product Information
CAS No.2351106-38-0
FormulaC15H12BrN3O5
M.W.394.18
SolubilitySoluble in DMSO
Storage/StabilityStore at -20°C
BackgroundPomalidomide-amido-C1-Br is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker. Pomalidomide-amido-C1-Br can be used to design a B-Raf PROTAC degrader PROTAC B-Raf degrader 1 (HY-111758). PROTAC B-Raf degrader 1 has anti-cancer activity.
Chen H, et al. Pomalidomide hybrids act as proteolysis targeting chimeras: Synthesis, anticancer activity and B-Raf degradation. Bioorg Chem. 2019 Jun;87:191-199.
Chen H, et al. Pomalidomide hybrids act as proteolysis targeting chimeras: Synthesis, anticancer activity and B-Raf degradation. Bioorg Chem. 2019 Jun;87:191-199.
Price840$
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