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PROTAK™ dBET57
$360/ 5mg
Specification
QuantityTotal: $360
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Product Information
CAS No.1883863-52-2
FormulaC34H31ClN8O5S
M.W.699.18
SolubilitySoluble in DMSO
Storage/StabilityStore at -20°C
BackgrounddBET57 is a potent and selective degrader of BRD4BD1 based on the PROTAC technology. dBET57 mediates recruitment to the CRL4CRBN E3 ubiquitin ligase, with a DC50/5h of 500 nM for BRD4BD1, and is inactive on BRD4BD2. BRD4 (BD1)|500 nM (DC50)
Nowak RP, et al. Plasticity in binding confers selectivity in ligand-induced protein degradation. Nat Chem Biol. 2018 Jul;14(7):706-714.
Nowak RP, et al. Plasticity in binding confers selectivity in ligand-induced protein degradation. Nat Chem Biol. 2018 Jul;14(7):706-714.
Price360$
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