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PROTAK™ PROTAC Sirt2-binding moiety 1
$1320/ 5mg
Specification
QuantityTotal: $1320
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Product Information
CAS No.1862237-99-7
FormulaC21H20N4O2S2
M.W.424.54
SolubilitySoluble in DMSO
Storage/StabilityStore at -20°C
BackgroundPROTAC Sirt2-binding moiety 1 is a selective and highly potent Sirtuin 2 (Sirt2) inhibitor, with an IC50 of 2.4 μM. For the development of sirtuin rearranging ligands (SirReals)-based PROTAC[1]. IC50: 2.4 μM (Sirt2).
Schiedel M, et al. Chemically Induced Degradation of Sirtuin 2 (Sirt2) by a Proteolysis Targeting Chimera (PROTAC) Based on Sirtuin Rearranging Ligands (SirReals). J Med Chem. 2018 Jan 25;61(2):482-491.
Schiedel M, et al. Chemically Induced Degradation of Sirtuin 2 (Sirt2) by a Proteolysis Targeting Chimera (PROTAC) Based on Sirtuin Rearranging Ligands (SirReals). J Med Chem. 2018 Jan 25;61(2):482-491.
Price1320$
Number: E31P34741-1,E31P34741-2 Name: PROTAK™ PROTAC Sirt2-binding moiety 1
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