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PROTAK™E3 ligase Ligand 8 hydrochloride
$1080/ 100mg
Specification
QuantityTotal: $1080
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
FormulaC17H22ClN3O3
M.W.351.83
SolubilitySoluble in DMSO
Storage/StabilityStore at -20°C
BackgroundE3 ligase Ligand 8 hydrochloride (compound 24) is a Ligand of BET for E3 Ligase used in PROTAC, with IC50 values of 0.98 nM and 13.7 nM in RS4;11 and MOLM-13 cells, respectively[1]. E3 ligase.
Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2018 Jan 25;61(2):462-481.
Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2018 Jan 25;61(2):462-481.
Price1080$
E31P34565-1,E31P34565-2 PROTAK™ E3 ligase Ligand 8 hydrochloride
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