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PROTAK™ PROTAC BET degrader-2

E31P32980-1DatasheetCOAMSDS
$1310/ 5mg
Specification
Quantity
Total: $1310

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Product Information

CAS No.2093388-33-9
Purity>98.00%
FormulaC41H42N10O6
M.W.770.84
SolubilityDMSO : 50 mg/mL (64.86 mM; Need ultrasonic);H2O : < 0.1 mg/mL (insoluble)
Storage/StabilityStore at -20°C
BackgroundPROTAC BET degrader-2 is a highly potent degrader of Bromodomain and Extra-Terminal (BET) proteins with an IC50 value of 9.6 nM in cell growth inhibition in the RS4;11 cells and capable of achieving tumor regression.
PROTAC BET degrader-2 (compound 25) is a highly potent degrader of Bromodomain and Extra-Terminal (BET) proteins with an IC50 value of 9.6 nM in cell growth inhibition in the RS4;11 cells and capable of achieving tumor regression[1].
[1]. Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2018 Jan 25;61(2):462-481.
Price1310$
📄Datasheet
Full product datasheet (PDF)✅Certificate of Analysis
Lot-specific COA (generated from product data)🧪MSDS
Material safety data sheet (generated)

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