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PROTAK™ PROTAC Linker 1
$600/ 100mg
QuantityTotal: $600
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Product Information
CAS No.1835705-53-7
Purity>98.00%
FormulaC14H27ClO4
M.W.294.81
SolubilityDMSO : ≥ 50 mg/mL (169.60 mM)
Storage/StabilityStore at -20°C
BackgroundROTAC Linker 1 is a PROTAC linker utilized to connect the respective tyrosine kinase inhibitor (TKI) to the E3 recruiting ligand.PROTAC technology employs small molecules that recruit target proteins for ubiquitination and removal by the proteasome. The synthesis of PROTAC compounds that mediate the degradation of c-ABL and BCR-ABL by recruiting either Cereblon or Von Hippel Lindau E3 ligases is reported. PROTAC Linker 1 is designated as 6-2-2. Lai AC, et al. Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL. Angew Chem Int Ed Engl. 2016 Jan 11;55(2):807-10.
Price600$
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