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PROTAK™ dBET6
$290/ 5mg
Specification
QuantityTotal: $290
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Product Information
CAS No.1950634-92-0
Purity>98.00%
FormulaC42H45ClN8O7S
M.W.841.37
SolubilityDMSO : ≥ 100 mg/mL (118.85 mM);H2O : < 0.1 mg/mL (insoluble)
Storage/StabilityStore at -20°C
BackgrounddBET6 is a highly potent, selective and cell-permeable degrader of BET based on PROTAC, with an IC50 of 14 nM, and has antitumor activity.dBET6 is a highly potent, selective and cell-permeable degrader of BET with an IC50 of 14 nM. dBET6 (100 nM) exhibits antitumor activity against T cell acute lymphoblastic leukemia (T-ALL) lines via degradation of BRD4.dBET6 (7.5 mg/kg, p.o., BID) reduces the leukemic burden in a disseminated mouse model of T-ALL.
Price290$
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