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PROTAK™ Protein degrader 1 hydrochloride
$640/ 100mg
Specification
QuantityTotal: $640
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
CAS No.1448189-80-7
Purity>98.00%
FormulaC22H31ClN4O3S
M.W.467.02
SolubilityDMSO : 150 mg/mL (321.19 mM; Need ultrasonic);H2O : 50 mg/mL (107.06 mM; Need ultrasonic)
Storage/StabilityStore at -20°C
BackgroundProtein degrader 1 hydrochloride is used in the synthesis of HaloPROTACs.Small molecule-induced protein degradation is an attractive strategy for the development of chemical probes.Protein degraders have the power to abrogate all of the functions of a drug target at once, including scaffolding functions which are difficult to target with small molecule inhibitors. A novel class of PROTACs that incorporate small molecule VHL ligands to successfully degrade HaloTag7 fusion proteins is developed. HaloPROTACs will inspire the development of future PROTACs with more drug-like properties. In HEK 293 cellsstably expressing GFP-HaloTag7,24 hour treatment with HaloPROTAC1 leads to less than 20% degradation, the longer HaloPROTAC2 leads to nearly 70% degradation of GFP-Halotag7 at 2.5 uM.HaloPROTACs containing protein degrader 1 leads to nearly 70% degradation of GFP-HaloTag7, when sufficiently long linkers are used
Price640$
Conjugated Antibody
This product is also available conjugated. Format: E31P19302-1-Conjugate. Price: $485 / Size: 100μl.
E31P19302-1-FITC$485 / 100μlE31P19302-1-Biotin$485 / 100μlE31P19302-1-HRP$485 / 100μlE31P19302-1-AP$485 / 100μlE31P19302-1-AF350$485 / 100μlE31P19302-1-AF405M$485 / 100μlE31P19302-1-AF488$485 / 100μlE31P19302-1-AF514$485 / 100μlE31P19302-1-AF532$485 / 100μlE31P19302-1-AF555$485 / 100μlE31P19302-1-AF568$485 / 100μlE31P19302-1-AF405S$485 / 100μlE31P19302-1-AF405L$485 / 100μlE31P19302-1-AF546$485 / 100μlE31P19302-1-AF594$485 / 100μlE31P19302-1-AF610$485 / 100μlE31P19302-1-AF635$485 / 100μlE31P19302-1-AF647$485 / 100μlE31P19302-1-AF680$485 / 100μlE31P19302-1-AF700$485 / 100μlE31P19302-1-AF750$485 / 100μlE31P19302-1-AF790$485 / 100μlE31P19302-1-APC$485 / 100μlE31P19302-1-PE$485 / 100μlE31P19302-1-Cy3$485 / 100μlE31P19302-1-Cy5$485 / 100μlE31P19302-1-Cy5.5$485 / 100μlE31P19302-1-Cy7$485 / 100μlE31P19302-1-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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