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PROTAK™ Nutlin-3a chiral
$240/ 10mg
Specification
QuantityTotal: $240
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Product Information
CAS No.675576-98-4
Name4-amino-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
Purity>98.00%
FormulaC30H30Cl2N4O4
M.W.581.49
Solubility≥29.0745 mg/mL in DMSO, ≥104.4 mg/mL in EtOH, <2.08 mg/mL in H2O
Storage/StabilityStore at -20°C
BackgroundNutlin-3 is a small-molecule inhibitor of MDM2 (mouse double minute 2) with IC50 value of 0.09μM Nutlin-3 binds MDM2 in the TP53-bindingpocket, thereby interfering with MDM2-directed TP53 degradation. This has been shown to cause cell cycle arrest, growth inhibitionand apoptosis in both solid tumors and lymphoid neoplasms.In mantle cell lymphoma(MCL), it is reported that Nutlin-3 can inhibit cell growth and activate apoptosis in bothwt-TP53(IC50 of 1 to 10μM) and mt-TP53(IC50 of 22.5μM) cells .
Nutlin-3 can also effectcell cycle in gastric cancer cell lines. It induces G1 arrest inMKN-45 and SNU-1 cell lines. In vitro assay shows Nutlin-3can enhance the antitumoreffects of conventional chemotherapeutic agents in several gastric cancer cell lines. And in in vivo assay, Nutlin-3 significantly inhibits the growth of xenograft tumors.
Nutlin-3 can also effectcell cycle in gastric cancer cell lines. It induces G1 arrest inMKN-45 and SNU-1 cell lines. In vitro assay shows Nutlin-3can enhance the antitumoreffects of conventional chemotherapeutic agents in several gastric cancer cell lines. And in in vivo assay, Nutlin-3 significantly inhibits the growth of xenograft tumors.
Price240$
Number: E31P10470-1, E31P10470-2 PROTAK™ Nutlin-3a chiral 10mg, 50mg 675576-98-4 4-amino-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
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