Mouse Erbb2 Rabbit Polyclonal Antibody (P1236)
Datasheet
Catalog Number:
E28PB3261Amount:
100ulPrice:
255$Altername:
Receptor tyrosine-protein kinase erbB-2, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, p185erbB2, CD340, Erbb2, Kiaa3023, NeuApplications:
WBReactivity:
Human, Rat, MouseSwiss-Prot No.:
P70424Specificity:
This Mouse Erbb2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1236-1268 amino acids from the Mouse Erbb2.Recommended Dilutions:
WB~~1:2000Predicted Molecular Weight:
139kDaForm of Antibody:
LiquidStorage/Stability:
Shipped at 4°C. Upon delivery aliquot and store at -20°C for one year. Avoid freeze/thaw cycles.Isotype:
Rabbit IgBackground:
Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization (By similarity).Tissue Expression:
Expressed predominantly in uterine epithelial cells. In the muscle, expression localizes to the synaptic sites of muscle fibersCellular localization:
Cell membrane {ECO:0000250|UniProtKB:P04626}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P04626} Early endosome {ECO:0000250|UniProtKB:P04626}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:P04626}. Nucleus {ECO:0000250|UniProtKB:P04626}. Note=Translocation to the nucleus requires endocytosis, probably endosomal sorting and is mediated by importin beta-1/KPNB1. Also detected in endosome-to-TGN retrograde vesicles. {ECO:0000250|UniProtKB:P04626}
- Anti-Erbb2 Antibody (P1236) at 1:2000 dilution + SK-BR-3 whole cell lysate
Lysates/proteins at 20 µg per lane.
Secondary
Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution.
Predicted band size : 139 kDa
Blocking/Dilution buffer: 5% NFDM/TBST.
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Catalog Number
- Amount:100ul
- Price:255$
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