Phospho-EGFR-T669 Rabbit pAb
Datasheet
Catalog Number:
E2530025Amount:
100ulPrice:
225$Swiss-Prot No.:
P00533Altername:
EGFRStorage/Stability:
Store at -20°C. Avoid freeze / thaw cycles.Immunogen:
A phospho specific peptide corresponding to residues surrounding T669 of human EGFRPurification:
Affinity purifiedReactivity:
HumanOther Names:
ERBB; HER1; mENA; ERBB1; PIG61; NISBD2Cellular localization:
Cell membrane, Endoplasmic reticulum, Endosome, Golgi apparatus, Membrane, Nucleus, SecretedRelevance:
Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin. Plays a role in enhancing learning and memory performance .Source:
RabbitAntibody type:
Polyclonal antibodyIsotype:
Rabbit IgGMolecular Weight:
200kDaPreservative:
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.Recommended Dilutions:
WB 1:500 - 1:2000; IP 1:50 - 1:100(Optimal dilutions should be determined by the end user)
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Catalog Number
- Amount:100ul
- Price:225$
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